Investigación de Columbia y Harvard revelan que las células cerebrales dañadas que están más involucradas en ELA de lo pensadoContributed by: AdminStaff1 · Views: 1,136
Contributed by: AdminStaff1 · April 15, 2007 @ 05:14 AM MDT · Views: 1,136
Columbia, Harvard Research Reveals Diseased Brain Cells More Involved In
ALS-Associated Motor Neuron Death Than Previously Thought
Implications for Stem Cell Research, Earlier ALS Diagnosis, More Targeted Interventions
Serge Przedborski, M.D., Ph.D.
Astrocyte Cells Not Spectators, But Key Players “It was previously thought that astrocytes were merely spectators watching their neighboring motor neurons die,” said Dr. Przedborski, who is the Page & William Black Professor of Neurology and professor of pathology and cell biology at Columbia’s College of Physicians & Surgeons. “With these results, we have learned they are not just spectators, they are major players. The astrocytes and their cellular environment are specifically causing motor neuron death.
“If these cell culture findings are faithfully modeling the situation occurring in ALS, then blocking the toxic factor released by astrocytes as early as possible could become an effective neuroprotective strategy against this disease,” Dr. Przedborski added. “Currently, we diagnose ALS at a point when a large number of motor neurons are already gone. As we learn more about astrocytes and the toxic factor or factors they release, we may be able to screen people for elevated levels of these proteins and intervene in a tangible way perhaps even before a person displays any clinical sign of ALS.”
Dr. Przedborski’s vision is to eventually test for the “biomarkers” of astrocytes and toxic factors in human ALS patients and then neutralize these factors early in the process thereby stalling or eliminating the degeneration of motor neurons and the onset of debilitating ALS symptoms.
Additional Columbia researchers who contributed to this study include: Tetsuya Nagata, M.D., Ph.D., Diane B. Re, Ph.D. and Makiko Nagai, M.D., Ph.D. of the Center for Motor Neuron Biology and Disease; Alcmène Chalazonitis, Ph.D. from the Department of Pathology and Cell Biology; Thomas Jessell, Ph.D., professor of biochemistry and molecular biophysics, Howard Hughes Medical Institute investigator, and director and research adviser for the Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research; and, Hynek Wichterle, Ph.D., assistant professor of pathology, whose seminal work in 2002 showed that mouse stem cells could be manipulated to become motor neurons.
The Columbia’s team astrocyte findings were corroborated in another Nature Neuroscience study authored by Kevin Eggan, Ph.D., Thomas Maniatis, Ph.D. and colleagues at Harvard University and the Harvard Stem Cell Institute. Harvard and Columbia researchers discovered their similar research through ongoing collaboration with the Project A.L.S./Jenifer Estess Laboratory for Stem Cell Research in New York.
This work was supported by the National Institute of Neurological Disorders and Stroke, the U.S. Department of Defense, the Muscular Dystrophy Association/Wings-over-Wall Street, the ALS Association, the Parkinson’s Disease Foundation, the Bernard and Anne Spitzer Fund, and Project A.L.S.
Columbia University Medical Center provides international leadership in pre-clinical and clinical research, in medical and health sciences education, and in patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, nurses, dentists, and public health professionals at the College of Physicians & Surgeons, the College of Dental Medicine, the School of Nursing, the Mailman School of Public Health, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. www.cumc.columbia.edu
Elizabeth Streich, Columbia University Medical Center
Courtesy: Columbia University Medical Center