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Microneedles: Flu Vaccine in Painless Skin Patches under Development at Emory and Georgia Tech with $11.5 Million in NIH Grants
Image shows an array of microneedles against a microscope image.
Georgia Tech Photo: Gary Meek
"A vaccine administered through a skin patch would have a number of advantages, including less discomfort to the recipients, lower cost and reduced production time," said Richard Compans, professor of microbiology and immunology in the Emory School of Medicine. "Potentially, individuals could administer the vaccine to themselves, perhaps after receiving it in the mail."
The Georgia Tech and Emory team plans to develop and assess the effectiveness of transdermal patches that include arrays of microscopic needles containing or coated with vaccine. They hope to design patches that could be stored for long periods of time at room temperature and that will increase the breadth and duration of immunity to influenza – perhaps with smaller amounts of vaccine.
“We expect that this research will lead to a better way of delivering the flu vaccine, which will allow more people who need it to receive the immunization in a convenient and effective way,” said Mark Prausnitz, a professor in the Georgia Tech School of Chemical and Biomolecular Engineering. “Beyond that, the possibility of replacing a hypodermic needle with a microneedle patch should significantly impact the way that other vaccines are delivered.”
The project team has extensive experience in microneedle development, influenza vaccines, vaccine delivery systems, product development and interdisciplinary collaboration. Beyond influenza, the research could have implications for immunization programs in developing countries, where eliminating the use of hypodermic needles could make vaccines more widely available and address the problem of disease transmission caused by the re-use of conventional hypodermic needles.
Researchers Mark Prausnitz (left) of Georgia Tech and Richard Compans of Emory University
are leading efforts to develop a new way to deliver the flu vaccine using microneedles.
Georgia Tech Photo: Gary Meek
Prausnitz and his colleagues have been working since the mid 1990s to develop microneedle technology for painless drug and vaccine delivery through the skin. Much smaller than conventional hypodermic needles, the microneedles in the arrays are made of titanium, stainless steel or various polymers – including some that could dissolve into the skin, carrying vaccine with them. The Georgia Tech team has also developed manufacturing processes for microneedle patches and tested the ability of the needles to deliver proteins, vaccines, nanoparticles, and small and large molecules through the skin.
"We expect microneedles to be less painful than conventional hypodermic needles because they are too small to significantly stimulate nerve endings," Prausnitz explained. "The NIH grants will allow us to move forward with perfecting the manufacturing process, refining the techniques for optimally inserting the microneedles into the skin and ensuring that vaccine delivered this way produces the necessary immune response.”
Compans and Prausnitz are the principal investigators on these grants. Other members of the microneedle research teams include Emory microbiologists Joshy Jacob, David Steinhauer, Chinglai Yang, and Ioanna Skountzou, Georgia Tech bioengineers Mark Allen, Harvinder Gill and Vladimir Zarnitsyn, and pharmaceutical scientist James Birchall at Cardiff University.
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Credits: Georgia Tech Research News