Las nuevas células cerebrales escuchan antes de poder hablarContributed by: Anonymous · Views: 1,267
Contributed by: Anonymous · October 31, 2007 @ 11:20 AM MDT · Views: 1,267
New Brain Cells Listen Before They TalkNew Haven, Conn. — Newly created neurons in adults rely on signals from distant brain regions to regulate their maturation and survival before they can communicate with existing neighboring cells—a finding that has important implications for the use of adult neural stem cells to replace brain cells lost by trauma or neurodegeneration, Yale School of Medicine researchers report in The Journal of Neuroscience.
Charles Greer and Mary Whitman
It was established in previous studies that several regions of the adult brain continue to generate new neurons, which are then integrated into existing brain circuitry. However the mechanisms that allowed this to happen were not known.
Using retrograde viruses, adult born neurons were labeled with green fluorescent protein (GFP) as shown in (A). The markers of synaptic connectivity were double labeled to follow the maturation and connectivity of the green-labeled cells.
They found that new neurons continue to mature for six to eight weeks after they are first generated and that the new neurons receive input from higher brain regions for up to 10 days before they can make any outputs. The other brain regions then continue to provide information to the new neurons as they integrate into existing networks.
The discovery of this previously unrecognized mechanism is significant, said Greer, because “if we want to use stem cells to replace neurons lost to injury or disease, we must ensure that they do not fire inappropriately, which could cause seizures or cognitive dysfunction.”
Press Contact: Jacqueline Weaver
Credits: Yale University