Nuevo gen de susceptibilidad descubierto para pancreatitis crónicaContributed by: Anonymous · Views: 910
Contributed by: Anonymous · December 03, 2007 @ 01:45 PM MST · Views: 910
NEW SUSCEPTIBILITY GENE DISCOVERED FOR CHRONIC PANCREATITIS
CTRC named new “bad guy” of disease
Sahin-Toth’s team was the first to suggest earlier this year that the product of the CTRC gene, the digestive enzyme chymotrypsin C, plays an important role in the cause of chronic pancreatitis.
“Up to this point, researchers only studied trypsin as the bad guy of chronic pancreatitis,” Sahin-Toth says. “Now we can look at chymotrypsin C activity to help us treat the disease.”
CTRC is the first susceptibility gene for chronic pancreatitis discovered since 2000 and only the fourth overall.
Sahin-Toth and researchers from the University of Leipzig and Charité University Hospital in Germany found mutations in the CTRC gene prevent the proper regulation of trypsin levels, leaving more trypsin in the pancreas. High levels of trypsin are known to lead to pancreatitis.
Doctors will now be able to screen patients to learn if alterations in the CTRC gene cause their patients’ cases of pancreatitis.
Chronic pancreatitis is a progressive, inflammatory disease that leads to digestive problems, chronic pain, possible diabetes, and eventual destruction of the pancreas. The disease has no cure and the rate of hospitalization and costs associated with the disease are high.
More information about Dr. Sahin-Toth’s research appears in Nature Genetics online December 2 at http://dx.doi.org/10.1038/ng.2007.44.
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