Virus de ingeniería de Yale que puede matar tumores cerebrales malignosContributed by: AdminStaff1 · Views: 1,226
Contributed by: AdminStaff1 · February 22, 2008 @ 08:58 AM MST · Views: 1,226
Yale Lab Engineers Virus That Can Kill Deadly Brain TumorsNew Haven, Conn. — A laboratory-engineered virus that can find its way through the vascular system and kill deadly brain tumors has been developed by Yale School of Medicine researchers, it was reported this week in the Journal of Neuroscience.
Human glioblastoma cells with red fluorescent protein
Green color is widespread viral infection of the tumor mass
Mouse brain with two human brain tumor grafts targeted by virus
To test their tumor-targeting virus, van den Pol and his team transplanted tumor tissue from human or mouse brains into the brains of mice. They then inoculated the mice with a lab-created vesicular stomatitis virus, a replicating virus distantly related to the rabies virus.
Selective infection of the red tumor by green virus
The team also tested targeting brain tumors with the virus through the olfactory nerve and found it led to complete infection of the tumor. After infection, the tumor cells disappeared from the olfactory bulb, van den Pol said.
Co-authors include lead author Koray Özduman, Guido Wollmann, and Joseph Piepmeier.
Journal of Neuroscience: February 20, 2008
PRESS CONTACT Jacqueline Weaver 203-432-8555
Credits & Courtesy: Yale University