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Demasiado de una buena cosa. La reparación excesiva del ADN puede llevar a la degeneración de la retina

Too much of a good thing
Excessive DNA repair can lead to retinal degeneration

Anne Trafton, News Office

A naturally occurring DNA repair system that normally protects cells from damage can cause retinal degeneration and blindness when overstimulated, according to a new study by MIT researchers.


Image courtesy / Samson Laboratory
MIT researchers found that mice with normal DNA repair systems had
more retinal degeneration upon exposure to environmental toxic agents
than mice lacking a certain DNA repair system. At right, the cross section
of the retina from a mouse lacking the repair system is normal. At left, mice
with too much DNA repair have greatly reduced numbers of cells in the OPL
(outer plexiform layer) and ONL (outer nuclear layer).


Neurocientíficos identifican fuente de declive cognitivo en los cerebros que envejecen

Neuroscientists ID source of cognitive decline in aging brains
Memory suffers when brain-communication network decays

Anne Trafton, News Office

As people age, memory and the ability to carry out tasks often decline. Scientists looking for ways to lessen that decline often have focused on the "gray matter" -- the cortical regions where high-level functions such as memory are located.

Otros talentos de Viagra: ayudar a una proteína señalizadora a proteger el corazón de daño por presión arterial alta

VIAGRA’S OTHER TALENTS: TO HELP A ‘SIGNALING’ PROTEIN SHIELD THE HEART FROM HIGH BLOOD PRESSURE DAMAGE

Johns Hopkins and other researchers report what is believed to be the first direct evidence in lab animals that the erectile dysfunction drug sildenafil amplifies the effects of a heart-protective protein. 

El tratamiento prolongado de nevirapina en bebés lactando previene la infección por VIH pero lleva a un VIH resistente a drogas

Prolonged Nevirapine in Breast-Fed Babies Prevents HIV Infection But Leads To Drug-Resistant HIV

Babies born to HIV-positive mothers and given the antiretroviral drug nevirapine through the first six weeks of life to prevent infection via breast-feeding are at high risk for developing drug-resistant HIV if they get infected anyway, a team of researchers report. But the investigators highlight the proven superiority of the six-week regimen in preventing mother-to-child HIV transmission in breast-fed infants.

Nanopartículas de oro entregan más que un destello

Gold particles deliver more than just glitter
Nanoparticles could carry drugs to treat cancer, other diseases

Anne Trafton, News Office

Using tiny gold particles and infrared light, MIT researchers have developed a drug-delivery system that allows multiple drugs to be released in a controlled fashion.


The top image shows a mixture of gold nanoparticles. The longer particles are called
nanobones, and the smaller are nanocapsules. Bottom left: After the nanoparticles are
hit with 800 nanometer wavelength infrared light, the nanocapsules melt and release their
payload. Nanobones remain intact. Right: After the nanoparticles are hit with 1100 nanometer
wavelength infrared light, the nanobones melt and release their payload. Nanocapsules
remain intact. Image / Andy Wijaya


Porqué los pacientes con cáncer de próstata fallan a la terapia hormonal de privación

WHY PROSTATE CANCER PATIENTS FAIL HORMONE DEPRIVATION THERAPY

--Johns Hopkins scientists identify receptor type that makes cancer cells resistant to therapy, more aggressive

Luces brillantes, pupilas no tan dilatadas

BRIGHT LIGHTS, NOT-SO-BIG PUPILS

December 31, 2008-  A team of Johns Hopkins neuroscientists has worked out how some newly discovered light sensors in the eye detect light and communicate with the brain. The report appears online this week in Nature

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