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No hay momento que perder en la terapia para el infarto agudo

Not a Moment to Lose in Therapy for Acute Stroke

By Debra Kain

In an editorial response to a report in the September 25 issue of The New England Journal of Medicine on the efficacy of intravenous thrombolysis treatment in the hours after acute ischemic stroke, Patrick Lyden, M.D., professor of neurosciences and director of the UC San Diego Stroke Center, cautions that the study should not be interpreted to mean that such therapy can be withheld for hours or even minutes.
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La mitocondria podría ser el objetivo terapéutico para los pacientes con enfermedad de Alzheimer

Mitochondria Could Be a Target for Therapeutic Strategy for Alzheimer’s Disease Patients

New York (Sept. 21, 2008) — A study in the Sept. 21 on-line edition of Nature Medicine describes the function and interaction of a critical molecule involved in cell death in Alzheimer’s disease patients. These new findings reveal that blocking this molecule, called Cyclophilin D (CypD), and development of surrounding mitochondrial targets may be viable therapeutic strategies for the prevention and treatment of Alzheimer’s disease, according to Shi Du Yan, Ph.D., professor of clinical pathology in the Department's of Pathology and Surgery and in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain at Columbia University Medical Center, who led the multi-center research.
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Investigadores de Yale encuentran bacteria 'amigable' que protege contra la diabetes tipo 1

‘Friendly’ Bacteria Protect Against Type 1 Diabetes, Yale Researchers Find

New Haven, Conn. — In a dramatic illustration of the potential for microbes to prevent disease, researchers at Yale University and the University of Chicago showed that mice exposed to common stomach bacteria were protected against the development of Type I diabetes.

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Novedoso mecanismo anti-cáncer es encontrado en roedores de larga vida

Novel Anti-Cancer Mechanism Found in Long-Lived Rodents

Biologists at the University of Rochester have found that small-bodied rodents with long lifespans have evolved a previously unknown anti-cancer mechanism that appears to be different from any anticancer mechanisms employed by humans or other large mammals. The findings are published in today's issue of Aging Cell.
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Porqué la quimio funciona para unos y no para otros

Why chemo works for some people and not others
MIT cell findings could predict individuals' responses

Anne Trafton, News Office

MIT researchers have shown that cells from different people don't all react the same way when exposed to the same DNA-damaging agent -- a finding that could help clinicians predict how patients will respond to chemotherapy.
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Estudio indica que monitorear el nivel exhalado de óxido nítrico en adolescentes con asma y ajustar el tratamiento no lo mejora

A new study shows that monitoring levels of exhaled nitric oxide in adolescents with asthma and adjusting treatment accordingly does not improve the course of their disease.

The study was conducted by the Inner City Asthma Consortium (ICAC), which is funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH). The Sept. 20 issue of The Lancet reports the ICAC findings.
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Equipo de Scripps Research reversa los síntomas de la enfermedad de Huntington en ratones

Scripps Research Team Reverses Huntington's Disease Symptoms in Mice
Experimental Treatment is Being Readied for Further Testing

LA JOLLA , CA, September 15, 2008—There is no cure for Huntington's disease, or even treatments that can reverse or slow progression of the devastating movement deficits and cognitive dysfunction that occur with the condition. But, now, an agent developed by scientists at The Scripps Research Institute has shown dramatic therapeutic efficacy in experimental mice, and did so with minimal toxicity.
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El empleo tópico de estradiol puede estimular la producción de colágeno en la piel que envejece

TOPICAL USE OF ESTRADIOL MAY STIMULATE COLLAGEN PRODUCTION IN AGING SKIN

CHICAGO—Applying the hormone estradiol to skin protected from the sun appears to stimulate production of the protein collagen in older men and women, according to a report in the September issue of Archives of Dermatology, one of the JAMA/Archives journals. However, it may not have the same effect on sun-exposed skin, such as the face or arms.
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Estudio provee pistas de como las células cancerígenas desarrollan resistencia a la quimioterapia

Study Provides Clues about How Cancer Cells Develop Resistance to Chemotherapy Drug

Researchers have shown that increased expression of a gene called SIRT1 in cancer cells plays a significant role in the development of resistance to the chemotherapy drug cisplatin. The SIRT1 gene, which regulates several important cellular processes including nutrient use and metabolism, appears to contribute to the development of cisplatin resistance by reducing the uptake and use of glucose by cells and by altering the function of their mitochondria, which are cellular structures that produce most of the energy in cells. These findings, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and colleagues, were published in the Sept. 15, 2008, issue of Molecular Cancer Research.
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Neurocientíficos de Johns Hopkins descubren un escalón inicial en la formación de la memoria

JOHNS HOPKINS NEUROSCIENTISTS DISCOVER A CRITICAL EARLY STEP OF MEMORY FORMATION
—Paradoxical Mechanism: Turn It Off In Order To Turn It On

Researchers at the Johns Hopkins University School of Medicine report in the July issue of Neuron how nerve cells in the brain ensure that Arc, a protein critical for memory formation, is made instantly after nerve stimulation. Paradoxically, its manufacture involves two other proteins — including one linked to mental retardation — that typically prevent proteins from being made.
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Investigadores de Johns Hopkins suprimen la "hormona del hambre"

JOHNS HOPKINS RESEARCHERS SUPPRESS “HUNGER HORMONE”
--New Minimally Invasive Method Tested in Pigs Yields Result as Good as Bariatric Surgery

Johns Hopkins scientists report success in significantly suppressing levels of the “hunger hormone” ghrelin in pigs using a minimally invasive means of chemically vaporizing the main vessel carrying blood to the top section, or fundus, of the stomach. An estimated 90 percent of the body’s ghrelin originates in the fundus, which can’t make the hormone without a good blood supply.
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Los analgésicos comunes bajan los niveles de los biomarcadores del cáncer de próstata

Common Painkillers Lower Levels of Prostate Cancer Biomarker

Common painkillers like aspirin and ibuprofen appear to lower a man’s PSA level, the blood biomarker widely used by physicians to help gauge whether a man is at risk of prostate cancer.
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Investigadores de Penn identifican supresor natural de tumor

Penn Researchers Identify Natural Tumor Suppressor  
Better Understanding of Early-Stage Cancer Crucial to Finding New Therapies

PHILADELPHIA - Researchers from the University of Pennsylvania School of Medicine have identified a key step in the formation – and suppression – of esophageal cancers and perhaps carcinomas of the breast, head, and neck. By studying human tissue samples, they found that Fbx4, a naturally occurring enzyme, plays a key role in stopping production of another protein called Cyclin D1, which is thought to contribute to the early stages of cancer development.
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Descubrimiento reta credo fundamental sobre la biología del cáncer

Discovery Challenges Fundamental Tenet of Cancer Biology


Hui Li and Jeffrey Sklar identify unexpected chimeras
in normal uterine tissue. (Credit: K.Henderson/Yale)

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Investigadores ofrecen la primer prueba directa de como la artritis destruye el cartílago

Researchers Offer First Direct Proof of How Arthritis Destroys Cartilage

A team of orthopaedic researchers has found definitive, genetic proof of how the most common form of arthritis destroys joint cartilage in nearly 21 million aging Americans, according to a study published today onlinein the Journal of Bone and Mineral Research. The findings serve as an important foundation for the design of new treatments for osteoarthritis (OA), researchers said.

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Investigadores divisan medio para crear sangre al identificar en forma temprana las células madre

RESEARCHERS DEVISE MEANS TO CREATE BLOOD BY IDENTIFYING EARLIEST STEM CELLS

Johns Hopkins researchers have discovered the earliest form of human blood stem cells and deciphered the mechanism by which these embryonic stem cells replicate and grow.  They also found a surprising biological marker that pinpoints these stem cells, which serve as the progenitors for red blood cells and lymphocytes.
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Investigadores de Stanford reportan haber encontrado un detonador temprano para la diabtes tipo 1 en ratones

Early trigger found for type-1 diabetes in mice, Stanford scientists report

By ERIN DIGITALE

STANFORD, Calif. — Scientists at the Stanford University School of Medicine are shedding light on how type-1 diabetes begins.
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Investigadores de Yale encuentran como los estrógenos ayudan a la memoria

Yale Researchers Find How Estrogen Aids Memory

New Haven, Conn. — Yale University researchers reported Tuesday they have found a molecular mechanism by which estrogen improves memory, a finding that may aid the quest to improve cognition in aging women without the negative health effects of hormone therapy. 
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Inyectisoma, potente arma de E. coli enteropatógena

Injectisome, a potent weapon of the enteropathogenic E. coli
Its attack is the main cause of death for diarrea in kids under 5 years old

Su ataque es la principal causa de muerte por diarrea en niños menores de cinco años
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Los vasos sanguíneos promueven la migración de los neuroblastos

Blood vessels promote migration of neuroblasts

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