Bioartificial kidney improves survival of patients with acute renal failure

Una prueba en varios centros conducida por la UM encuentra que el reemplazo a corto plazo de la función de célula renal con un aparato de asistencia de túbulo renal reduce en 50 por ciento el riesgo de mortalidad.

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Characterization of the protein causing ATR-X syndrome

Investigación ganadora de una de las Becas para las Mujeres en la Ciencia L’Oréal 2007

Viviana Valadéz Graham, investigadora posdoctoral del Instituto de Biotecnología de la UNAM (IBt), está caracterizando la proteína ATRX en Drosophila melanogaster, cuya mutación está asociada en los seres humanos al síndrome ATRX (alfa talasemia y retraso mental ligados al cromosoma X).
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INR Researchers find markers linked to osteoporosis

Enfermedad discapacitante considerada un problema de salud pública mundial

La doctora Rocío Gómez y el maestro en ciencias Jonathan Magaña, ambos investigadores del Departamento de Genética del Instituto Nacional de Rehabilitación (INR) de la Secretaría de Salud, descubrieron marcadores asociados con la pérdida de la densidad mineral ósea, es decir, el aumento a la predisposición de osteoporosis. Dos de estos marcadores se ubican en el gen de la calcitonina (CT) y en el gen del receptor de estrógeno alfa (ER-a).En forma paralela, encontraron marcadores protectores contra esta enfermedad en el gen receptor de interleucina-6 (IL-6) y de la vitamina D (VDR).
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Scientists Identify Novel Way to Prevent Cardiac Fibrosis

By Debra Kain

In a study that points to a new strategy for preventing or possibly reversing fibrosis – the scarring that can lead to organ and tissue damage – researchers at the University of California, San Diego School of Medicine have determined that a molecule called Epac (Exchange protein activated by cAMP1), plays a key role in integrating the body’s pro- and anti-fibrotic response. The research will be published in the online edition of the Proceedings of the National Academy of Science (PNAS) the week of April 21.
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Researchers Detail Chemotherapy's Damage to the Brain

A commonly used chemotherapy drug causes healthy brain cells to die off long after treatment has ended and may be one of the underlying biological causes of the cognitive side effects – or “chemo brain” – that many cancer patients experience. That is the conclusion of a study published today in the Journal of Biology.
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Stem Cells and Embriology

Horacio Merchant Larios, Departamento de Biología Celular y Fisiología del IIB

La posibilidad de generar células de reemplazo a partir de células troncales, avanza con celeridad acercando la posibilidad de su aplicación a la medicina regenerativa. Dos son los principales motores del auge cobrado por esta nueva área de investigación: El desarrollo de nuevos métodos analíticos de biología molecular y las elevadas inversiones de fondos públicos y privados que se otorgan en los países desarrollados. Además, de igual importancia para el avance del área ha resultado el empleo del método científico basado en el conocimiento sistematizado y bien fundamentado en observaciones y experimentos rigurosos. El empirismo oportunista basado en experimentos de ensayo y error con resultados irrepetibles ha desprestigiado el área y dificultado su avance.
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UNAM researchers discover a region in the TRPV1 receptor that allows perceiving painfull stimulus
First report on the importance of cistein in the activation of the channel involved

LAURA ROMERO

Se reporta por primera vez la importancia de la cisteína en la activación del canal involucrado
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Two stroke-prevention procedures are neck-and-neck down the long stretch

Después de tres años, pacientes de alto riesgo logran resultados parecidos con cirugía mínimamente invasiva con la colocación de stents o una cirugía abierta en las arterias carótidas del cuello
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BLOOD VESSELS: THE PIED PIPER FOR GROWING NERVE CELLS

Researchers at Johns Hopkins have discovered that blood vessels in the head can guide growing facial nerve cells with blood pressure controlling proteins. The findings, which suggest that blood vessels throughout the body might have the same power of persuasion over many nerves, are published this week in Nature.
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An unexpected way to cause leukaemia

New mouse model grants insight into the genetic and molecular mechanisms underpinning acute myeloid leukaemia
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HOPKINS PERFORMS HISTORIC "SIX-WAY DOMINO" KIDNEY TRANSPLANT
Six donor-recipient pairs interchange kidneys in simultaneous group procedure

Surgical teams at Johns Hopkins performed what is believed to be the first six-way donor kidney swap among 12 individuals Saturday, April 5. The 10-hour surgeries used six operation rooms and occupied nine surgical teams at The Johns Hopkins Hospital.
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An unexpected way to cause leukaemia
New mouse model grants insight into the genetic and molecular mechanisms underpinning acute myeloid leukaemia

Leukaemia – cancer of blood or bone marrow – is caused by mutations that allow defective blood cells to accumulate and displace healthy blood. To devise effective therapies it is crucial to know which mutations cause leukaemia and which cell type gives rise to leukaemic cells. Researchers from the European Molecular Biology Laboratory [EMBL] in Italy, the EMBL-European Bioinformatics Institute, UK, and the Universities of Harvard, USA, and Lund, Sweden, have now used genetic engineering to introduce a mutation found in human leukaemia patients into mice. In the current issue of Cancer Cell they report that the mutation causes leukaemia by triggering innate genetic programmes that allow white blood cells to proliferate uncontrollably. The findings have implications for the way leukaemia should be treated.
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New Species of Infectious Disease Found in Amazon

By Debra Kain

While investigating the tropical disease leptospirosis in the Peruvian Amazon, an infectious disease specialist from the University of California, San Diego School of Medicine has uncovered new, emerging bacteria that may be responsible for up to 40 percent of cases of the disease. Patients with severe forms of leptospirosis have jaundice, renal failure and lung hemorrhage, with high fatality rates.
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Fitness Study Shows Differences in Blood Vessel Repair, Fat Hormone

Fit healthy people tend to have higher numbers of circulating cells that regenerate blood vessels, a new study from Emory University shows. Findings were presented March 30 at the American College of Cardiology's 57th Annual Scientific Session in Chicago.
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LARGE MULTI-CENTER STUDY SHOWS OLDER CORNEAS SUITABLE FOR TRANSPLANTS
Could Expand Donor Pool Significantly

In what could be a landmark, federally funded study, a team of scientists and a national team of researchers have shown that transplantation of corneas from older donors have rates of success similar to those from younger donors.
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Study Shows Why Synthetic Estrogens Wreak Havoc on Reproductive System

New Haven, Conn. — Researchers at Yale School of Medicine now have a clearer understanding of why synthetic estrogens such as those found in many widely-used plastics have a detrimental effect on a developing fetus, cause fertility problems, as well as vaginal and breast cancers.
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Hormone That Controls Hunger and Appetite Also Linked to Reduced Fertility

New Haven, Conn. — Researchers at Yale School of Medicine have found that in-utero exposure to the hormone grhelin, a molecule that controls appetite and hunger and nutrition, can result in decreased fertility and fewer offspring.
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Scientists Find a Key Culprit in Stroke Brain Cell Damage

Researchers have identified a key player in the killing of brain cells after a stroke or a seizure. The protein asparagine endopeptidase (AEP) unleashes enzymes that break down brain cells' DNA, scientists at Emory University School of Medicine have found.
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Studying proteins that inhibit blood vessel growth
The process, called angiogenesis, is linked to diseases like, cancer, diabetic retinopathy and arthritis.

Laura Romero

El proceso, denominado angiogénesis, está vinculado con la gestación de padecimientos como cáncer, retinopatía diabética y artritis

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