Team Led by Scripps Research Scientists Uncovers New Way to Limit Damaging Production of Nitric Oxide
Results Could Lead to New Treatments for Conditions From Inflammation to Cancer
LA JOLLA, CA, October 12, 2008—Excess nitric oxide production by one enzyme has been tied to human illnesses ranging from inflammation to cancer, but adequate treatments for the problem have been elusive. Now, work led by scientists at The Scripps Research Institute has revealed a new method for chemically targeting this single enzyme to block troubling nitric oxide production, without limiting its beneficial production by other closely related enzymes. This technique provides a general solution that should enable development of new drugs to treat medical problems tied to nitric oxide overproduction, such as arthritis, and may also aid the discovery of treatments for other conditions such as HIV/AIDS.
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