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Drugs & Technologies

Estudio apunta a variación genética que eleva el riesgo de complicaciones serias ligadas a droga para osteoporosis

Study Pinpoints Genetic Variation that Raises Risk of Serious Complication Linked to Osteoporosis Drugs

Findings could lead to screening test for determining who can safely take these medicines
New York, NY (January 26, 2012) — Researchers at the Columbia University College of Dental Medicine have identified a genetic variation that raises the risk of developing serious necrotic jaw bone lesions in patients who take bisphosphonates, a common class of osteoclastic inhibitors. The discovery paves the way for a genetic screening test to determine who can safely take these drugs. The study appears in the online version of the journal The Oncologist.
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Nuevo fármaco encontrado como efectivo contra rara forma de carcinoma de piel de células basales

New Drug Found Effective Against Rare Form of Basal Cell Skin Cancer

Targeted molecular therapy – taken orally – offers alternative to surgical removal

New York, NY (June 6, 2012) — A clinical study has demonstrated that a new drug, a targeted molecular therapy called vismodegib (trade name Erivedge™), can dramatically shrink basal cell skin cancers and prevent the formation of new ones, in patients with basal cell nevus syndrome (BCNS). This rare genetic condition causes dozens, and sometimes hundreds or thousands, of skin cancers on each patient’s body. The primary treatment option is surgical removal. These study results are significant as they indicate the possibility of an alternative treatment with oral medication; although side effects remain a consideration.

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La aspirina y la warfarina son efectivas para la mayoría de los pacientes con falla cardiaca

A 10-year multi-center study found that aspirin and the blood thinner warfarin (brand name Coumadin®) were equally effective at preventing a combined risk of death, stroke, and cerebral hemorrhage in heart failure patients with normal heart rhythm.

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Estudio identifica potencial tratamiento para leucemia letal en niños

Study Identifies Potential Treatment for Lethal Childhood Leukemia

Inhibiting two related enzymes significantly improves survival in mouse model of the disease
New York, NY (April 16, 2012) — Columbia University Medical Center (CUMC) scientists have demonstrated that two related enzymes — phosphoinositide-3 kinase (PI3K) gamma and delta — play a key role in the development of T-cell acute lymphoblastic leukemia (T-ALL), a highly aggressive childhood leukemia that is difficult to treat. The study also showed that a dual PI3K gamma/delta inhibitor can significantly prolong survival in a mouse model of the disease. Further, the dual inhibitor was shown to prevent proliferation and to reduce the survival rate of human T-ALL cells in laboratory cultures, setting the stage for clinical trials. The study appears today in the online edition of Cancer Cell.

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Estudio de Penn advierte cuidado en el uso de drogas para bloquear el sonrojarse por niacina en pacientes cardiacos

Penn Study Cautions Use of Drugs to Block "Niacin Flush" in Heart Patients

PHILADELPHIA — Niacin, or vitamin B3, is the one approved drug that elevates "good" cholesterol (high density lipoprotein, HDL) while depressing "bad" cholesterol (low density lipoprotein , LDL), and has thereby attracted much attention from patients and physicians. Niacin keeps fat from breaking down, and so obstructs the availability of LDL building blocks.

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Manufactura contínua de medicamentos ofrece velocidad, costos bajos

Continuous drug manufacturing offers speed, lower costs

New system developed by MIT researchers could help transform the pharmaceutical industry.

Anne Trafton, MIT News Office

Researchers at the Novartis-MIT Center for Continuous Manufacturing built this drug-manufacturing prototype in an MIT chemical engineering lab. The system, which consists of six connected units, can transform raw ingredients into finished drug tablets.
Photo: Dominick Reuter

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Nueva clase de medicamentos inhibe la inflamación en el cerebro

New class of potential drugs inhibits inflammation in brain

Scientists at Emory University School of Medicine have identified a new group of compounds that may protect brain cells from inflammation linked to seizures and neurodegenerative diseases.

Neurons staining bright green are a sign of damage induced by a prolonged seizure. Compounds that block the prostaglandin receptor EP2 can prevent this damage.

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La interacción entre moléculas es clave a reacción de fármaco, de auerdo a investigadores de la UF

Interaction between molecules key to dangerous drug reaction, UF researchers find

GAINESVILLE, Fla. — University of Florida researchers have helped identify the underlying cause of a genetically derived, potentially fatal reaction to an anti-HIV medication, and have begun creating a less dangerous form of the drug.

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La estatinas pueden proteger de la muerte por aneurisma de acuerdo a estudio de Yale

Statins may protect against death from aneurysm, Yale study finds

By Helen Dodson

A study by Yale School of Medicine reveals that survival rates for patients with a thoracic aneurysm are significantly better, and complications are fewer, among patients who take statin cholesterol drugs than those who do not. The study appears in the American Journal of Cardiology.

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La progesterona inhibe el crecimiento de las células

Progesterone inhibits growth of neuroblastoma cancer cells

Neuroblastoma, the most common form of cancer affecting small children.

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Científicos de Scripps Research desarrollan nueva clase de moléculas pequeñas a través de una química novedosa

Scripps Research Scientists Develop Brand New Class of Small Molecules through Innovative Chemistry

Novel Approach Could Greatly Expand, Accelerate Drug Discovery Process

JUPITER, FL, November 20, 2011—Inspired by natural products, scientists on the Florida campus of The Scripps Research Institute have created a new class of small molecules with the potential to serve as a rich foundation for drug discovery.

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Investigadores de Yale descubren prometedores agentes anti VIH

Yale researchers discover promising anti-HIV agents

By Eric Gershon

Researchers at Yale University have discovered new chemical compounds that prevent HIV from replicating in human T-cells. These compounds could result in new, highly effective HIV treatments that are 10 to 2000 times more potent than HIV drugs now on the market.

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Estudio encuentra que un medicamento para disminuir la presión arterial posterior a derrame ayuda en la recuperación

Blood pressure-lowering drug after stroke aids recovery, study finds

Medication works possibly by helping the opposite brain side.

Writer: Kathleen Raven

Athens, Ga. - A commonly prescribed blood pressure-lowering medication appears to kick start recovery in the unaffected brain hemisphere after a stroke by boosting blood vessel growth, a new University of Georgia study has found.

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Deteniendo la artritis antes de que comience

Stopping arthritis before it starts

A commonly used drug may prevent osteoarthritis in people who suffer severe joint injuries.

Anne Trafton, MIT News Office

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Nuevo medicamento podría curar casi cualquier infección viral

New drug could cure nearly any viral infection

Researchers at MIT’s Lincoln Lab have developed technology that may someday cure the common cold, influenza and other ailments.

Anne Trafton, MIT News Office

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Fumadores usando Vareniclina para dejar de fumar están en riesgo de ataque cardiaco y otros problemas

Smokers Using Varenicline to Quit the Habit at Greater Risk of Heart Attack or Other Serious Heart Problems

Popular antismoking drug increases chance of serious cardiac event by 72 percent compared to people on placebo, study find.

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Científicos de Scripps Research y el MIT descubren clase de compuestos con potencial anti-cáncer

Scripps Research and MIT Scientists Discover Class of Potent Anti-Cancer Compounds

Findings may lead to new therapies for cancer and Alzheimer's disease patients.

LA JOLLA, CA, AND JUPITER, FL – March 7, 2011 – Working as part of a public program to screen compounds to find potential medicines and other biologically useful molecules, scientists from The Scripps Research Institute and Massachusetts Institute of Technology (MIT) have discovered an extremely potent class of potential anti-cancer and anti-neurodegenerative disorder compounds. The scientists hope their findings will one day lead to new therapies for cancer and Alzheimer’s disease patients.

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Prototipo de medicamento apunta al metabolismo y detiene la enfermedad que limita el trasplante de médula ósea

Drug prototype points metabolism and stops the disease that limits bone marrow transplantation

ANN ARBOR, Michigan.— Un prototipo de medicamento que ya se ha mostrado prometedor en el tratamiento de trastornos autoinmunes, como lupus, artritis y psoriasis detiene la enfermedad de injerto versus anfitrión (GVHD por su sigla en inglés) en modelos con ratones de trasplante de médula ósea, según muestra una investigación de la Universidad de Michigan y la Universidad de Florida.

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Químicos sintetizan compuesto de hongo con actividad anti-cáncer

Chemists synthesize fungal compound with anti-cancer activity

Anne Trafton, News Office

Graphic courtesy / Mohammad Movassaghi
Structural diagram of (+)-11,11'-Dideoxyverticillin A. MIT chemists
recently synthesized the compound, which has shown anti-cancer activity,
for the first time.

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Nuevo gel ofrece una liberación controlada del medicamento

New gel offers controlled drug delivery
Self-assembling hydrogel could help treat cancer and diabetes, among other diseases

Anne Trafton, News Office

MIT researchers have demonstrated that a gel composed of small, woven protein fragments can successfully carry and release proteins of different sizes, potentially enabling delivery of drugs such as insulin and trastuzumab (Herceptin).
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