Scripps Research Scientists Identify Protein that Sends ‘Painful Touch’ Signals

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Scripps Research Scientists Identify Most Lethal Known Species of Prion Protein
Findings Suggest New View of “Mad Cow” and Other Neurodegenerative Diseases

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Study Shows Alzheimer’s Disease May Spread by ‘Jumping’ from One Brain Region to Another

Findings open new opportunities for studying Alzheimer’s and testing potential therapies

New York, NY (February 1, 2012) — For decades, researchers have debated whether Alzheimer’s disease starts independently in vulnerable brain regions at different times, or if it begins in one region and then spreads to neuroanatomically connected areas. A new study by Columbia University Medical Center (CUMC) researchers strongly supports the latter, demonstrating that abnormal tau protein, a key feature of the neurofibrillary tangles seen in the brains of those with Alzheimer’s, propagates along linked brain circuits, “jumping” from neuron to neuron.

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Proteins linked to longevity may be involved in mood control

Anne Trafton, MIT News Office

Leonard Guarente, the Novartis Professor of Biology Photo: Donna Coveney

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Powerful Approach to the Analysis of Protein Motions

DXMS analysis provides novel tool for studying how movements allow proteins to perform their functions as molecular machines.

Debra Kain

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Scripps Research Scientists Develop Powerful New Methodology for Stabilizing Proteins

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Stanford scientists pinpoint key proteins in blood stem cell replication

BY KRISTA CONGER

STANFORD, Calif. - A family of cancer-fighting molecules helps blood stem cells in mice decide when and how to divide, say researchers at the Stanford University School of Medicine. Blocking the molecules' function spurs the normally resting cells to begin proliferating strangely - making too much of one kind of cell and not enough of another. Many types of human blood cancers involve a similar disruption in the expression of that same family of molecules.
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New way to control protein activity could lead to cancer therapies, Stanford study shows

BY BRUCE GOLDMAN

STANFORD, Calif. — Investigators at the Stanford University School of Medicine have found a way to quickly and reversibly fine-tune the activity of individual proteins in cells and living mammals, providing a powerful new laboratory tool for identifying — more precisely than ever before — the functions of different proteins.
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Scientists Find “Redesigned Hammer” That Forged Evolution of Pregnancy in Mammals

Vincent Lynch: “Resurrected genes from the extinct ancestors
of mammals helped us find a change that promoted development
of the uterus and placenta.” (credit Wagner/Yale)

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